Endocrine Abstracts

Medullary thyroid carcinoma (MTC) is hereditary in 25 per cent of cases. This may be in association with Multiple Endocrine Neoplasia (MEN) Type 2 (A and B) or as familial MTC (FMTC) alone. The mutations causing hereditary forms of MTC arise in the RET-proto-oncogene.A 40 yr old asymptomatic gentleman presenting with a mass in his neck. Fine needle aspiration of the mass revealed a probable medullary thyroid carcinoma. Total thyroidectomy and neck dissec...

A 55 year old lady presented to our hospital in 1991 with a year's history of diarrhoea, weight loss and abdominal pain. On examination, she had 5cm hepatomegaly. Serum gastrin was elevated (148 pmol per litre NR < 40), as was GAWK (276 pmol per litre NR < 150). Basal gastric acid secretion was increased (39 mmol per hour NR < 5). CT abdomen showed multiple hepatic metastases, confirmed to be neuroendocrine in origin on biopsy. There were no clinical or biochemical fe...